Kawasaki Disease / Болезнь Кавасаки
Тексты / Научно-техническая литература / Естественные науки
Kawasaki disease is an idiopathic self-limiting systemic vasculitis that most often affects children in the age range 6 months to 5 years. It predominantly affects children of Asian origin, particularly Japanese and Chinese populations (possibly because of genetic susceptibility) but there is an appreciable worldwide incidence. It was first described in 1967 by Tomisaku Kawasaki, a Japanese paediatrician.
It was originally thought to be a troubling but benign illness but it was later realised that deaths and significant morbidity occur through its major complication of coronary artery aneurysm formation. It has taken over from rheumatic fever as the most common cause of acquired childhood heart disease in the developed world. Prior to its delineation, cases had been described and classified on histological grounds as infantile polyarteritis/periarteritis nodosa. Early diagnosis and early treatment are now strongly advocated to reduce complications and have been shown to do so.
Its characteristic features are outlined below:
Classical features of Kawasaki disease
Fever lasting ≥5 days.
Marked irritability of the child.
Erythema, swelling and desquamation affecting the skin of the extremities.
Bilateral conjunctivitis.
Rash.
Inflammation of the lips, mouth and/or tongue.
Cervical lymphadenopathy.
It was originally thought to be a troubling but benign illness but it was later realised that deaths and significant morbidity occur through its major complication of coronary artery aneurysm formation. It has taken over from rheumatic fever as the most common cause of acquired childhood heart disease in the developed world. Prior to its delineation, cases had been described and classified on histological grounds as infantile polyarteritis/periarteritis nodosa. Early diagnosis and early treatment are now strongly advocated to reduce complications and have been shown to do so.
Its characteristic features are outlined below:
Classical features of Kawasaki disease
Fever lasting ≥5 days.
Marked irritability of the child.
Erythema, swelling and desquamation affecting the skin of the extremities.
Bilateral conjunctivitis.
Rash.
Inflammation of the lips, mouth and/or tongue.
Cervical lymphadenopathy.
Оглавление:
| Название | Статус | Активность | Готово | |
|---|---|---|---|---|
| Epidemiology | переводится | > 1 года | 50% (3 / 6) | читать |
| Aetiology and pathophysiology | — | 0% (0 / 4) | ||
| Symptoms | — | 0% (0 / 19) | ||
| Subsidiary features of the disease | — | 0% (0 / 7) | ||
| Differential diagnosis | — | 0% (0 / 12) | ||
| Investigations | — | 0% (0 / 8) | ||
| Management | — | 0% (0 / 5) | ||
| Aspirin | — | 0% (0 / 3) | ||
| IVIg | — | 0% (0 / 3) | ||
| Adjunctive therapy in refractory cases | — | 0% (0 / 10) | ||
| Complications | — | 0% (0 / 12) | ||
| Prognosis | — | 0% (0 / 7) | ||
Перевод
- Перевод:
- текст с английского на русский
- Создан:
- 11 сентября 2016, владелец: romanenkokarina
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