p2_tw: переводы

→Keywords: Cancer stem cells, Targeted therapy, Drug resistance

→Since their description and identification in leukemias and solid tumors, cancer stem cells (CSC) have been the subject of intensive research in translational oncology. Indeed, recent advances have led to the identification of CSC markers, CSC targets, and the preclinical and clinical evaluation of the CSC-eradicating (curative) potential of various drugs. However, although diverse CSC markers and targets have been identified, several questions remain, such as the origin and evolution of CSC, mechanisms underlying resistance of CSC against various targeted drugs, and the biochemical basis and function of stroma cell-CSC interactions in the so-called ‘stem cell niche.’ Additional aspects that have to be taken into account when considering CSC elimination as primary treatment-goal are the genomic plasticity and extensive subclone formation of CSC. Notably, various cell fractions with different combinations of molecular aberrations and varying proliferative potential may display CSC function in a given neoplasm, and the related molecular complexity of the genome in CSC subsets is considered to contribute essentially to disease evolution and acquired drug resistance. In the current article, we discuss new developments in the field of CSC research and whether these new concepts can be exploited in clinical practice in the future.

→Abstract

→The disruption of the blood-testis barrier in spermatoceles may result in antisperm antibody production and eventual infertility; however, cryopreservation can result in long-term options for owners seeking to continue using an animal in their breeding program.

→A spermatocele was confirmed on histopathology. After another month, an excellent-quality semen sample was collected, with 90% progressive motility, good concentration, and few morphologic abnormalities. A subsequent collection was acquired and was successfully cryopreserved for future breeding. In dogs with spermatoceles, semen quality can be preserved with aggressive treatment to remove the affected testicle.

→The abnormal texture and fluid-filled cavity in the right epididymis persisted, despite antibiotic therapy. Cytology of a repeat aspiration of the fluid-filled area after antibiotic therapy revealed a mixture of red blood cells and sperm. Owing to the potential for blood-testis barrier disruption, a unilateral orchiectomy of the right testicle was performed, as an attempt to protect future sperm production of the remaining testicle.

→Ultrasonography revealed that the enlarged area of the right epididymis was fluid filled. A sample of the fluid was aspirated for aerobic culture. No bacteria showed growth. Although the culture was negative, it was suspected that this dog had an epididymitis or epididymal abscess, and treatment with enrofloxacin at 10 mg/kg orally was initiated for 4 weeks.

→A 2-year-old intact male South African Boerboel presented for semen cryopreservation and was discovered to be azoospermic. The dog had excellent libido and had sired litters within 6 months, so a further investigation of why his collection lacked sperm was warranted. On further examination of his scrotal contents, his right epididymis had an enlarged area with a hard texture.

→I disagree with this rule as well. Better, I say, to break any of these rules you like, but only after you acknowledge that each has its justifications and if you remain alert, in your writing, to abuses of the English language they caution against. But “Orwell, or else” is a policy that smacks of rigidity.

→Am I prohibited from referring to an eminence grise, in favor of “power behind the throne” or “puppet master”? The French phrase for “gray eminence,” or “gray man,” is admittedly somewhat pretentious, but it’s also a rich metaphor — and if you don’t know what it means, after you look it up, your word-hoard is in turn enriched. Likewise, scientific terminology and topic-specific jargon can become tiresome, but it’s often appropriate in moderation.

→The case for active language is often strong. But passive constructions are acceptable when the actor in a sentence (in the following sentence’s case, the “seer”) is not significant: “Punk music can be seen as a reaction to the overblown theatricality of disco and arena rock.” And sometimes the object is more important than the subject. Yes, favor active voice, but don’t categorically prohibit occasional passive structure.

→Um, is always really necessary in that sentence? And “Omit a word” is more concise than “cut a word out.” But omit has more letters than cut. Do you see where this is going? The answer is, too far. Striving to attain Hemingwayesque conciseness is appropriate for assembly instructions, and journalistic writing should be as transparent as possible, but Bill Bryson never met an adjective or an adverb he didn’t like, and if anyone’s complained about that, I haven’t read the grievance. In moderation (or, in Bryson’s case, in excess), modification is merited.

→Utilization of sesquipedalian vocabulary unquestionably mitigates comprehension, but never is dishearteningly uncompromising. Better to advise minimizing multisyllabism. But must I always write do in place of accomplish? Spread instead of disseminate? Try in favor of endeavor? That’s an oddly totalitarian rule, coming from Orwell.

→6. Break any of these rules sooner than say anything outright barbarous.

→5. Never use a foreign phrase, a scientific word, or a jargon word if you can think of an everyday English equivalent.

→4. Never use the passive where you can use the active.

→3. If it is possible to cut a word out, always cut it out.

→2. Never us a long word where a short one will do.

→Certainly, many figures of speech such as “bite the bullet,” “push the envelope,” and “go the extra mile” should be sent to the metaphor retirement home, and I’ve warned about buzzwords, but not every common figure of speech has worn out its welcome. They can be especially catchy when used in punny contexts: A government agency turns over a new leaf about deforestation, a rock band plays musical chairs with its lineup, a pharmaceutical company’s setback is a bitter pill to swallow.

→1. Never use a metaphor, simile, or other figure of speech which you are used to seeing in print.